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Nancy Campbell works primarily in screenprinting and lithography, often combining both processes in the same print. Throughout her career, Campbell's printmaking has been inspired in part by medieval Japanese scroll painting, which she has studied both in America and Japan. National Gallery curator Ruth Fine wrote of her work: "Campbell imbues her paintings on paper and her prints with a sense of structure held in tension with an erratic calligraphic movement.... We see a quest for unity between the logical and measured, the intuitive and spontaneous."

Campbell's work has been exhibited widely in national and international exhibitions and is included in numerous public collections, including the Philadelphia Museum of Art, the Library of Congress, and the Worcester Art Museum. Her prints appear in A Graphic Muse: Prints by Contemporary American Women (1987), a catalog of an exhibition at the º¬Ðß²ÝÑо¿Ëù Art Museum that documents the contributions that American women artists have made to contemporary printmaking.

In 1984, Campbell established the º¬Ðß²ÝÑо¿Ëù Printmaking Workshop, an artist-in-residence program that brings an accomplished woman artist to campus to create art and to serve as an inspiration for students. Past guest artists have included Kiki Smith, Elaine de Kooning, Joan Snyder, Vija Celmins, and Sondra Freckelton.

Campbell has been a visiting artist at Michigan State University's program in Hikone, Japan, and at Trinity College; the University of Maine at Orono; University of Dallas; and Stewart and Stewart Prints, Bloomfield Hills, Michigan. Before coming to Mount Holyoke, she taught art at the University of Michigan; the University of Hartford, Hartford Art School; Oberlin College; and the Swain School of Design.